Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 39)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0056099	0.0998207	0.9557140
Weighted median	23	0.0301737	0.0546512	0.5808705
Inverse variance weighted	23	0.0336818	0.0390157	0.3879795
Simple mode	23	0.0203852	0.0893373	0.8216120
Weighted mode	23	0.0096561	0.0659365	0.8849033

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.06922	21	0.6446197
Inverse variance weighted	18.16257	22	0.6963074

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017239	0.0056423	0.7629722

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000573	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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