Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 38)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0222519	0.1313983	0.8671445
Weighted median	23	0.0085275	0.0633166	0.8928652
Inverse variance weighted	23	-0.0126732	0.0502775	0.8009906
Simple mode	23	0.0194073	0.1246656	0.8777092
Weighted mode	23	0.1154108	0.1107325	0.3086148

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.39067	21	0.0197553
Inverse variance weighted	36.53517	22	0.0265871

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021448	0.0074274	0.7755906

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011102	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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