Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 37)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0811464	0.1220152	0.5132557
Weighted median	23	0.0660862	0.0610439	0.2789856
Inverse variance weighted	23	0.0062407	0.0470850	0.8945571
Simple mode	23	0.0103007	0.1159988	0.9300440
Weighted mode	23	0.0622833	0.0742776	0.4107572

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.37726	21	0.0676045
Inverse variance weighted	32.04192	22	0.0766841

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046	0.0068969	0.5120595

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009717	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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