Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 36)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0572230	0.1334253	0.6723802
Weighted median	23	-0.0864398	0.0595281	0.1464781
Inverse variance weighted	23	-0.0824775	0.0510024	0.1058502
Simple mode	23	0.0753099	0.1120453	0.5084940
Weighted mode	23	-0.0855038	0.0638685	0.1943237

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.52028	21	0.0146602
Inverse variance weighted	37.59583	22	0.0203290

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015509	0.0075418	0.8390559

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012746	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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