Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 35)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0928223	0.1181318	0.4407886
Weighted median	23	0.0390337	0.0591212	0.5091058
Inverse variance weighted	23	0.0307742	0.0464780	0.5078910
Simple mode	23	0.0443977	0.1040799	0.6738352
Weighted mode	23	0.0443977	0.0805943	0.5872679

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.41129	21	0.1044720
Inverse variance weighted	31.22085	22	0.0916841

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00759	0.0066774	0.2684765

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009649	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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