Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 34)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1618804	0.1109537	0.1593643
Weighted median	23	-0.0274914	0.0555173	0.6204689
Inverse variance weighted	23	0.0150830	0.0452979	0.7391538
Simple mode	23	0.0027843	0.1034396	0.9787688
Weighted mode	23	-0.0309547	0.0608666	0.6161177

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.94582	21	0.2085225
Inverse variance weighted	29.65545	22	0.1270820

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0108673	0.0062716	0.0977985

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009032	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8