Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 32)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0098217	0.0998202	0.9225524
Weighted median	23	0.0136891	0.0543991	0.8013174
Inverse variance weighted	23	0.0128234	0.0390155	0.7424015
Simple mode	23	0.0731665	0.0928756	0.4392254
Weighted mode	23	0.0380136	0.0672366	0.5775429

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.85021	21	0.9137800
Inverse variance weighted	12.91095	22	0.9356149

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013906	0.0056423	0.8077152

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003945	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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