Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 31)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1827263	0.1251031	0.1589245
Weighted median	23	-0.0012356	0.0637596	0.9845392
Inverse variance weighted	23	0.0008971	0.0505303	0.9858350
Simple mode	23	-0.0676882	0.1287276	0.6042702
Weighted mode	23	0.0171745	0.0815596	0.8351561

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.98623	21	0.0463701
Inverse variance weighted	36.90278	22	0.0242434

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0111661	0.0070714	0.1292705

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011182	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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