Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 30)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1116582	0.0998209	0.2759497
Weighted median	23	-0.0592643	0.0531289	0.2646441
Inverse variance weighted	23	-0.0317775	0.0390156	0.4153687
Simple mode	23	-0.0466965	0.0893672	0.6065283
Weighted mode	23	-0.0715948	0.0601583	0.2466894

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.28326	21	0.6937990
Inverse variance weighted	18.03911	22	0.7036667

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049055	0.0056424	0.3944574

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005667	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8