Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 3)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0909562	0.0998198	0.3725297
Weighted median	23	-0.0955263	0.0551867	0.0834576
Inverse variance weighted	23	-0.0753804	0.0390154	0.0533511
Simple mode	23	-0.0995380	0.0919499	0.2907424
Weighted mode	23	-0.1024510	0.0653537	0.1312376

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.91620	21	0.5265745
Inverse variance weighted	19.94494	22	0.5864839

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009565	0.0056423	0.8670069

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007175	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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