Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 29)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0234464	0.1097251	0.8328552
Weighted median	23	-0.0692612	0.0594907	0.2443289
Inverse variance weighted	23	-0.0620922	0.0426104	0.1450588
Simple mode	23	-0.2248090	0.1221813	0.0793059
Weighted mode	23	0.0662521	0.0854594	0.4464475

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.37463	21	0.2313033
Inverse variance weighted	26.24138	22	0.2414630

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052529	0.0062022	0.4065743

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008719	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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