Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 28)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0387285	0.0998212	0.7019368
Weighted median	23	0.0391352	0.0543800	0.4717338
Inverse variance weighted	23	0.0212061	0.0390158	0.5867673
Simple mode	23	0.1042719	0.0882358	0.2499251
Weighted mode	23	0.0439407	0.0658371	0.5114476

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.63612	21	0.8847162
Inverse variance weighted	13.67249	22	0.9126944

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001076	0.0056424	0.8505862

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004233	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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