Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 27)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0381128	0.1147032	0.7429769
Weighted median	23	-0.0427679	0.0585201	0.4648865
Inverse variance weighted	23	-0.0473399	0.0438097	0.2798840
Simple mode	23	0.0133271	0.0955702	0.8903645
Weighted mode	23	-0.0248720	0.0677374	0.7169913

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.72881	21	0.1480115
Inverse variance weighted	27.73890	22	0.1844966

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005666	0.0064836	0.9311848

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008851	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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