Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 26)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0658186	0.1135921	0.5684637
Weighted median	23	-0.0174787	0.0635449	0.7832696
Inverse variance weighted	23	0.0333976	0.0442982	0.4508935
Simple mode	23	0.0808115	0.1200111	0.5077269
Weighted mode	23	-0.0743437	0.1395068	0.5994425

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.19578	21	0.1644665
Inverse variance weighted	28.36192	22	0.1639948

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060929	0.0064208	0.3534489

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008816	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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