Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 25)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1125729	0.1512009	0.4648095
Weighted median	23	0.0347294	0.0598060	0.5614417
Inverse variance weighted	23	-0.0156416	0.0588942	0.7905560
Simple mode	23	0.0421972	0.1267593	0.7423668
Weighted mode	23	0.0505099	0.0632567	0.4331220

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.18363	21	0.0006491
Inverse variance weighted	50.13098	22	0.0005630

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0078736	0.0085465	0.3673783

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015239	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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