Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 24)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1416466	0.1141977	0.2285214
Weighted median	23	-0.0177057	0.0549305	0.7472030
Inverse variance weighted	23	-0.0074498	0.0452698	0.8692874
Simple mode	23	-0.0480468	0.0953561	0.6193635
Weighted mode	23	-0.0152448	0.0636926	0.8130506

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.48534	21	0.1553600
Inverse variance weighted	29.61864	22	0.1280319

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.008241	0.0064549	0.2156504

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008986	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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