Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 23)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1868413	0.1033405	0.0849493
Weighted median	23	-0.0038038	0.0618345	0.9509483
Inverse variance weighted	23	-0.0571604	0.0411730	0.1650460
Simple mode	23	0.0273791	0.1030278	0.7929106
Weighted mode	23	0.0273791	0.0988500	0.7843845

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.50927	21	0.3706902
Inverse variance weighted	24.50156	22	0.3214984

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079639	0.0058414	0.1872126

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008074	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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