Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 22)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1839883	0.1237890	0.1520582
Weighted median	23	0.0972600	0.0660364	0.1407981
Inverse variance weighted	23	-0.0218874	0.0494978	0.6583513
Simple mode	23	0.1380730	0.1134423	0.2364535
Weighted mode	23	0.1136026	0.0922536	0.2311686

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.2981	21	0.0546031
Inverse variance weighted	35.4110	22	0.0350791

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0099548	0.0069973	0.1695179

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010826	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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