Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 21)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0129942	0.1082226	0.9055696
Weighted median	23	0.0036738	0.0571139	0.9487124
Inverse variance weighted	23	0.0206024	0.0413330	0.6181681
Simple mode	23	0.0592470	0.1010268	0.5635442
Weighted mode	23	0.0219018	0.0677148	0.7494151

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.68422	21	0.2610995
Inverse variance weighted	24.69108	22	0.3120745

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004672	0.0061172	0.9398424

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007567	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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