Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 20)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0003287	0.1224680	0.9978839
Weighted median	23	0.0255197	0.0589410	0.6650363
Inverse variance weighted	23	0.0035139	0.0467677	0.9401073
Simple mode	23	-0.0485903	0.1103245	0.6639222
Weighted mode	23	0.0091861	0.0702376	0.8971329

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.61016	21	0.0640856
Inverse variance weighted	31.61137	22	0.0842674

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001956	0.0069224	0.9777246

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009581	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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