Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 2)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0931185	0.1382470	0.5079333
Weighted median	23	-0.0506365	0.0621697	0.4153645
Inverse variance weighted	23	-0.0055194	0.0533850	0.9176545
Simple mode	23	0.0014940	0.1232639	0.9904386
Weighted mode	23	-0.0889650	0.0831556	0.2962795

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.28145	21	0.0068719
Inverse variance weighted	41.19047	22	0.0078213

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053794	0.0078144	0.4987333

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012487	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8