Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 19)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2004413	0.1184561	0.1054105
Weighted median	23	-0.0653564	0.0572659	0.2537538
Inverse variance weighted	23	-0.0513477	0.0472062	0.2767140
Simple mode	23	-0.0571405	0.0964901	0.5597610
Weighted mode	23	-0.1335102	0.0668058	0.0581713

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.57428	21	0.1008826
Inverse variance weighted	32.20757	22	0.0739255

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.009156	0.0066958	0.1859523

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010284	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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