Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 18)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1381790	0.0998205	0.1808097
Weighted median	23	-0.0339518	0.0549224	0.5364584
Inverse variance weighted	23	0.0282426	0.0390159	0.4691418
Simple mode	23	0.0403314	0.0953124	0.6762937
Weighted mode	23	-0.0186386	0.0606559	0.7615164

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.20976	21	0.6983150
Inverse variance weighted	20.49056	22	0.5523833

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0102199	0.0056423	0.0844239

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006368	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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