Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 17)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0584263	0.1042846	0.5812321
Weighted median	23	-0.0861389	0.0578374	0.1364005
Inverse variance weighted	23	-0.0341442	0.0398840	0.3919491
Simple mode	23	-0.1213004	0.1128302	0.2939927
Weighted mode	23	-0.1027617	0.0753265	0.1862939

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.92083	21	0.3482141
Inverse variance weighted	22.99068	22	0.4022562

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014912	0.0058947	0.8027535

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007199	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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