Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 16)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1227301	0.1085929	0.2711417
Weighted median	23	-0.0536289	0.0585222	0.3594645
Inverse variance weighted	23	-0.0594905	0.0418618	0.1552834
Simple mode	23	-0.1608763	0.1110986	0.1617058
Weighted mode	23	-0.0551162	0.0837303	0.5172015

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.85411	21	0.2535381
Inverse variance weighted	25.32786	22	0.2816544

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038836	0.0061382	0.5337689

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008379	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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