Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 15)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0901949	0.0998200	0.3764694
Weighted median	23	-0.0476775	0.0559571	0.3941936
Inverse variance weighted	23	0.0013734	0.0390154	0.9719193
Simple mode	23	-0.0299697	0.0843470	0.7257384
Weighted mode	23	-0.0688386	0.0687533	0.3275966

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.54211	21	0.5504066
Inverse variance weighted	20.53535	22	0.5495902

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056232	0.0056423	0.3302979

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006223	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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