Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 14)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1172841	0.0998196	0.2531615
Weighted median	23	-0.0638810	0.0555378	0.2500506
Inverse variance weighted	23	-0.0485438	0.0390154	0.2134183
Simple mode	23	-0.1696651	0.1067123	0.1261194
Weighted mode	23	-0.0865676	0.0672017	0.2110693

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.83606	21	0.5316654
Inverse variance weighted	20.39581	22	0.5582959

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042214	0.0056423	0.4626599

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000665	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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