Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 13)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0617033	0.1126648	0.5896919
Weighted median	23	0.0252249	0.0565570	0.6555914
Inverse variance weighted	23	0.0380021	0.0430768	0.3776718
Simple mode	23	0.0503205	0.0937019	0.5966384
Weighted mode	23	0.0262645	0.0637704	0.6844275

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.75183	21	0.1792192
Inverse variance weighted	26.81838	22	0.2182061

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014555	0.0063683	0.8214298

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008414	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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