Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 12)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2573476	0.1028535	0.0206851
Weighted median	23	0.1019125	0.0545615	0.0617835
Inverse variance weighted	23	0.0364926	0.0440736	0.4076754
Simple mode	23	0.0556763	0.0865658	0.5267632
Weighted mode	23	0.0997405	0.0551715	0.0843266

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.29607	21	0.3826244
Inverse variance weighted	28.07417	22	0.1732361

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0135627	0.0058138	0.0296818

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008771	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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