Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 11)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1856178	0.1113541	0.1103775
Weighted median	23	-0.0600993	0.0647047	0.3529803
Inverse variance weighted	23	0.0399922	0.0445205	0.3690321
Simple mode	23	-0.0491676	0.1131104	0.6680237
Weighted mode	23	-0.0690910	0.0921645	0.4614080

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.13502	21	0.2013474
Inverse variance weighted	28.64730	22	0.1552087

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0089431	0.0062944	0.1700549

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008999	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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