Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 10)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0385424	0.0998198	0.7032920
Weighted median	23	0.0433809	0.0580007	0.4544980
Inverse variance weighted	23	0.0049399	0.0390155	0.8992465
Simple mode	23	0.0388641	0.1047813	0.7142547
Weighted mode	23	0.0821764	0.0887291	0.3644175

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.30683	21	0.8974970
Inverse variance weighted	13.44059	22	0.9201407

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020635	0.0056423	0.7182283

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004078	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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