Two sample MR report

Telomere_length against rfMRI amplitudes (ICA100 node 1)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0726404	0.1215041	0.5563373
Weighted median	23	-0.1381250	0.0575730	0.0164341
Inverse variance weighted	23	-0.1047941	0.0464904	0.0241898
Simple mode	23	-0.2192439	0.1037786	0.0462145
Weighted mode	23	-0.1622198	0.0693683	0.0288516

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.11619	21	0.0717458
Inverse variance weighted	31.23867	22	0.0913342

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019746	0.0068681	0.7765465

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011652	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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