Two sample MR report

Telomere_length against aseg rh volume vessel

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1279164	0.1052657	0.2377848
Weighted median	23	0.0376797	0.0597728	0.5284453
Inverse variance weighted	23	-0.0246283	0.0424949	0.5622128
Simple mode	23	0.0479645	0.1278243	0.7110770
Weighted mode	23	0.0707884	0.0677471	0.3074188

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.54883	21	0.3154279
Inverse variance weighted	26.32814	22	0.2378604

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0093662	0.0059494	0.1303596

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00081	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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