Two sample MR report

Telomere_length against aseg rh volume choroid-plexus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2232570	0.1155622	0.0669739
Weighted median	23	0.0129871	0.0575427	0.8214382
Inverse variance weighted	23	0.0009292	0.0484929	0.9847122
Simple mode	23	-0.0259494	0.1012374	0.8000840
Weighted mode	23	0.0820881	0.0696643	0.2512507

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.38151	21	0.1296591
Inverse variance weighted	34.28540	22	0.0459371

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0136509	0.0065313	0.048959

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010389	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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