Two sample MR report

Telomere_length against aseg rh volume VentralDC

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0062838	0.1425544	0.9652568
Weighted median	23	-0.0827501	0.0578517	0.1526071
Inverse variance weighted	23	-0.0503119	0.0546662	0.3573915
Simple mode	23	-0.1160016	0.0915655	0.2184501
Weighted mode	23	-0.0784884	0.0607199	0.2095510

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.18780	21	0.0029745
Inverse variance weighted	43.57037	22	0.0040118

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034749	0.0080567	0.6706412

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001371	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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