Two sample MR report

Telomere_length against aseg rh volume Thalamus-Proper

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0781368	0.1141980	0.5013165
Weighted median	23	-0.0204421	0.0579315	0.7241880
Inverse variance weighted	23	0.0055512	0.0442530	0.9001729
Simple mode	23	0.0199031	0.1178837	0.8674680
Weighted mode	23	-0.0572499	0.0711719	0.4297791

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.71472	21	0.1484293
Inverse variance weighted	28.55122	22	0.1581250

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051385	0.0064542	0.4348605

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008658	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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