Two sample MR report

Telomere_length against aseg rh volume Putamen

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0296353	0.1303139	0.8223005
Weighted median	23	0.0003604	0.0606360	0.9952575
Inverse variance weighted	23	-0.0440298	0.0501974	0.3804145
Simple mode	23	0.0218336	0.1204955	0.8578711
Weighted mode	23	-0.0255891	0.0936056	0.7871174

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.09045	21	0.0213592
Inverse variance weighted	36.73861	22	0.0252659

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004523	0.007365	0.5457318

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011521	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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