Two sample MR report

Telomere_length against aseg rh volume Pallidum

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1802490	0.1618914	0.2781215
Weighted median	23	0.0176403	0.0598091	0.7680377
Inverse variance weighted	23	-0.0066852	0.0640818	0.9169127
Simple mode	23	-0.1073989	0.1386618	0.4468573
Weighted mode	23	-0.0228015	0.0686810	0.7430383

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	55.69928	21	5.59e-05
Inverse variance weighted	59.87300	22	2.33e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0114776	0.0091496	0.2234687

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001815	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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