Two sample MR report

Telomere_length against aseg rh volume Lateral-Ventricle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0243448	0.1103341	0.8274988
Weighted median	23	0.0136729	0.0582770	0.8145048
Inverse variance weighted	23	-0.0392224	0.0421464	0.3520485
Simple mode	23	0.0392412	0.0908795	0.6700934
Weighted mode	23	0.0513831	0.0607430	0.4067107

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.87146	21	0.2113926
Inverse variance weighted	25.89790	22	0.2560914

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009135	0.0062358	0.8849321

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008156	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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