Two sample MR report

Telomere_length against aseg rh volume Inf-Lat-Vent

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0246230	0.1261776	0.8471544
Weighted median	23	0.0253853	0.0566076	0.6538335
Inverse variance weighted	23	-0.0018330	0.0482328	0.9696851
Simple mode	23	-0.0093626	0.1002138	0.9264106
Weighted mode	23	0.0334683	0.0613377	0.5908029

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.83416	21	0.0377477
Inverse variance weighted	33.91776	22	0.0500781

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016244	0.0071312	0.8220165

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010279	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8