Two sample MR report

Telomere_length against aseg rh volume Hippocampus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1326762	0.1156028	0.2640036
Weighted median	23	0.0236448	0.0591607	0.6893997
Inverse variance weighted	23	0.0658996	0.0445478	0.1390599
Simple mode	23	0.0551406	0.1158952	0.6389219
Weighted mode	23	0.0248224	0.0861876	0.7760396

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.40115	21	0.1291366
Inverse variance weighted	28.93374	22	0.1467622

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041001	0.0065336	0.5370727

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000964	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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