Two sample MR report

Telomere_length against aseg rh volume Cortex

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1854928	0.1328123	0.1771050
Weighted median	23	-0.1706893	0.0587119	0.0036464
Inverse variance weighted	23	-0.0656949	0.0518532	0.2051765
Simple mode	23	-0.2023016	0.1231394	0.1146283
Weighted mode	23	-0.2065779	0.0793584	0.0162337

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.48840	21	0.0147856
Inverse variance weighted	39.20262	22	0.0133761

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0073556	0.0075063	0.3382767

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012746	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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