Two sample MR report

Telomere_length against aseg rh volume CerebralWhiteMatter

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1978051	0.1262486	0.1321092
Weighted median	23	-0.0655057	0.0574956	0.2545711
Inverse variance weighted	23	-0.0353818	0.0526195	0.5013234
Simple mode	23	0.0679035	0.0955669	0.4848381
Weighted mode	23	-0.0117846	0.0653701	0.8585873

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.87404	21	0.037380
Inverse variance weighted	40.36891	22	0.009787

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0143176	0.0071352	0.0578396

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012482	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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