Two sample MR report

Telomere_length against aseg rh volume Cerebellum-White-Matter

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0580964	0.1440661	0.6908317
Weighted median	23	-0.0040617	0.0614888	0.9473330
Inverse variance weighted	23	-0.0020960	0.0552723	0.9697502
Simple mode	23	-0.1281291	0.1311287	0.3391306
Weighted mode	23	0.0161304	0.0811636	0.8442920

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.10928	21	0.0022632
Inverse variance weighted	44.54203	22	0.0030324

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036958	0.0081423	0.6545549

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013498	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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