Two sample MR report

Telomere_length against aseg rh volume Cerebellum-Cortex

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0342565	0.1213644	0.7805064
Weighted median	23	0.0664034	0.0574431	0.2476872
Inverse variance weighted	23	0.0348783	0.0463359	0.4516133
Simple mode	23	0.1123074	0.0935614	0.2427660
Weighted mode	23	0.0758541	0.0614214	0.2298660

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.30278	21	0.0687644
Inverse variance weighted	31.30283	22	0.0900834

Test for directional horizontal pleiotropy

egger_intercept	se	pval
3.82e-05	0.0068592	0.9956112

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009729	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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