Two sample MR report

Telomere_length against aseg rh volume Caudate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1197651	0.1305555	0.3693749
Weighted median	23	-0.0443607	0.0598619	0.4586629
Inverse variance weighted	23	-0.0350178	0.0504313	0.4874520
Simple mode	23	-0.0699012	0.0958062	0.4733258
Weighted mode	23	-0.0988317	0.0653263	0.1445410

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.22367	21	0.0206333
Inverse variance weighted	37.08150	22	0.0231733

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052035	0.0073787	0.4884339

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011483	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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