Two sample MR report

Telomere_length against aseg rh volume Amygdala

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0960885	0.0994454	0.3449189
Weighted median	23	0.0558767	0.0564184	0.3219792
Inverse variance weighted	23	0.0137184	0.0388455	0.7239746
Simple mode	23	-0.2659547	0.0998638	0.0142026
Weighted mode	23	0.0597988	0.0689517	0.3951628

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.01654	21	0.4579343
Inverse variance weighted	21.82690	22	0.4702604

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0050575	0.0056204	0.3784059

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006652	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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