Two sample MR report

Telomere_length against aseg rh volume Accumbens-area

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0640887	0.1045732	0.5465498
Weighted median	23	-0.0837313	0.0535560	0.1179506
Inverse variance weighted	23	-0.0909805	0.0399993	0.0229327
Simple mode	23	-0.0450854	0.0895022	0.6194544
Weighted mode	23	-0.0955583	0.0588821	0.1188600

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.24031	21	0.3313005
Inverse variance weighted	23.32669	22	0.3834836

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016511	0.0059102	0.7826926

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008731	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

Funnel plot

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Leave-one-out sensitivity analysis

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