Two sample MR report

Telomere_length against aseg rh number HolesBeforeFixing

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0592525	0.1076839	0.5879573
Weighted median	23	0.0792290	0.0590324	0.1795546
Inverse variance weighted	23	0.1789923	0.0464246	0.0001155
Simple mode	23	0.1240593	0.1162402	0.2974239
Weighted mode	23	0.1013927	0.0679603	0.1499165

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.64418	21	0.2629034
Inverse variance weighted	31.42381	22	0.0877638

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0146281	0.006086	0.025554

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015955	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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