Two sample MR report

Telomere_length against aseg rh intensity vessel

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0256713	0.0994069	0.7987325
Weighted median	23	-0.0004377	0.0525891	0.9933589
Inverse variance weighted	23	-0.0017519	0.0388456	0.9640289
Simple mode	23	-0.0011618	0.0811478	0.9887056
Weighted mode	23	-0.0133849	0.0625013	0.8323992

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	6.848555	21	0.9984210
Inverse variance weighted	6.916888	22	0.9990724

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014686	0.0056182	0.7963259

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0002097	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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